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Article

Targeting the Phosphatidylinositol 3-Kinase Pathway in Multiple Myeloma

1 Jul 2007

Abstract excerpt

Multiple myeloma is a plasma cell neoplasm with a median survival of 3 to 5 years. Recent advances have improved patient outlook, but the disease remains incurable. Therefore, continued efforts to develop new therapies that target aberrant signaling pathways are needed. The phosphatidylinositol 3-kinase pathway regulates apoptosis, cell cycle regulation, and tumor proliferation. This pathway is constitutively...

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PMID: 17606706
DOI: 10.1158/1078-0432.ccr-06-2921

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