Article
Pan-Raf co-operates with PI3K-dependent signalling and critically contributes to myeloma cell survival independently of mutated RAS.
Leukemia - 1 Apr 2017
Müller E, Bauer S, Stühmer T, Mottok A, Scholz C-J, Steinbrunn T, Brünnert D, Brandl A, Schraud H, Kreßmann S, Beilhack A, Rosenwald A, Bargou R C, Chatterjee M
Abstract excerpt
Direct therapeutic targeting of oncogenic RAS is currently still impossible due to lack of suitable pharmacological inhibitors. Because specific blockade of druggable RAS effectors might represent an alternative treatment approach, we evaluated the role of the Raf complex for multiple myeloma (MM) pathobiology. We found frequent overexpression of the Raf isoforms (A-, B- and C-Raf) and downstream activation of...
Topics
- Apoptosis
- Cell Line, Tumor
- Cell Survival
- Drug Resistance, Neoplasm
- Enzyme Activation
- Gene Expression
- Gene Knockdown Techniques
- Humans
- Isoenzymes
- Lenalidomide