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Article

p110δ PI3K as a therapeutic target of solid tumours

1 Jun 2020

Abstract excerpt

From the time of first characterization of PI3K as a heterodimer made up of a p110 catalytic subunit and a regulatory subunit, a wealth of evidence have placed the class IA PI3Ks at the forefront of drug development for the treatment of various diseases including cancer. The p110α isoform was quickly brought at the centre of attention in the field of cancer research by the discovery of cancer-specific...

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PMID: 32556179
DOI: 10.1042/cs20190772

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