Article

Targeting AKT elicits tumor suppressive functions of FOXO transcription factors and GSK3 kinase in Multiple Myeloma

2019-10-24

Abstract excerpt

<h4>ABSTRACT</h4> The phosphatidylinositide-3 kinases (PI3K) and the downstream mediator AKT drive survival and proliferation of multiple myeloma (MM) cells and several AKT inhibitors are currently being tested in clinical trials for MM patients. AKT inhibition has pleiotropic effects, and the key aspects that determine therapeutic efficacy are not fully clear. Therefore, we investigated the antimyeloma mechanism...

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Literature Corpus work: d6166ddb-b7be-52ac-af73-2fff2144e89d
DOI: 10.1101/816694

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