Unc-51 Like Kinase 3 (ULK3) is essential for autophagy and cell survival in multiple myeloma

Abstract excerpt

<title>Abstract</title> <p>Despite the availability of effective therapies such as proteasome inhibitors, multiple myeloma (MM) patients relapse with refractory disease. To identify new therapeutic targets, we assessed RNA sequencing data from CD138+ MM patient cells (n = 813) across disease stages and found that an autophagy gene signature, and particularly ULK3 expression, was strongly associated with disease p...

Topics

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• Aged
• Autophagy
• Autophagy in Disease and Therapy
• Cancer Mechanisms and Therapy
• Endoplasmic Reticulum Stress and Disease
• Multiple Myeloma Research and Treatments
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

062773c6-21a0-5c39-827f-a0451bafb668

DOI

10.21203/rs.3.rs-7160521/v1