In trans complementation of lethal factor reveal roles in colonization and dissemination in a murine mouse model.

doi:10.1371/journal.pone.0095950

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

In trans complementation of lethal factor reveal roles in colonization and dissemination in a murine mouse model.

PloS one - 1 Jan 2014

Lowe David E, Ya Jason, Glomski Ian J

Abstract excerpt

Lethal factor (LF) is a component of the B. anthracis exotoxin and critical for pathogenesis. The roles of LF in early anthrax pathogenesis, such as colonization and dissemination from the initial site of infection, are poorly understood. In mice models of infection, LF-deficient strains either have altered dissemination patterns or do not colonize, precluding analysis of the role of LF in colonization and...

Topics

Animals
Anthrax
Antigens, Bacterial
Bacillus anthracis
Bacterial Toxins
Cell Line, Tumor
Disease Models, Animal
Host-Pathogen Interactions
Mice
Mutation
Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 24763227
DOI: 10.1371/journal.pone.0095950
PMCID: PMC3999102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics