Article
Mutation of luxS of Streptococcus pneumoniae affects virulence in a mouse model.
Infection and immunity - 1 Jun 2003
Stroeher Uwe H, Paton Adrienne W, Ogunniyi A David, Paton James C
Abstract excerpt
The LuxS protein is required for the biosynthesis of the type 2 autoinducer (AI-2), which is involved in quorum sensing in a wide range of bacterial species. We have determined the effects of a defined luxS mutation on the virulence of Streptococcus pneumoniae. Although the luxS mutant displayed reduced virulence relative to its wild-type parent, the type 2 strain D39, it was by no means avirulent in a mouse...
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