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Article

Hidden risk genes with high-order intragenic epistasis in Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Sun Jiya, Song Fuhai, Wang Jiajia, Han Guangchun, Bai Zhouxian, Xie Bin, Feng Xuemei, Jia Jianping, Duan Yong, Lei Hongxing

Abstract excerpt

Meta-analysis of data from genome-wide association studies (GWAS) of Alzheimer's disease (AD) has confirmed the high risk of APOE and identified twenty other risk genes/loci with moderate effect size. However, many more risk genes/loci remain to be discovered to account for the missing heritability. The contributions from individual singe-nucleotide polymorphisms (SNPs) have been thoroughly examined in...

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Share to Apolipoproteins E
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24762948
DOI: 10.3233/JAD-140054

Genes

APOE
FSHR
KIRREL3
PTPN5
RYR3
TEK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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