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Article

Translating Mendelian and complex inheritance of Alzheimer's disease genes for predicting unique personal genome variants.

Journal of the American Medical Informatics Association : JAMIA - 1 Jan 2000

Regan Kelly, Wang Kanix, Doughty Emily, Li Haiquan, Li Jianrong, Lee Younghee, Kann Maricel G, Lussier Yves A

Abstract excerpt

OBJECTIVE: Although trait-associated genes identified as complex versus single-gene inheritance differ substantially in odds ratio, the authors nonetheless posit that their mechanistic concordance can reveal fundamental properties of the genetic architecture, allowing the automated interpretation of unique polymorphisms within a personal genome. MATERIALS AND METHODS: An analytical method, SPADE-gen, spanning...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22319180
DOI: 10.1136/amiajnl-2011-000656
PMCID: PMC3277633

Genes

APOE
EPHA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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