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Article

ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism.

The Journal of clinical investigation - 1 Jun 2014

Yang Yanan, Ahn Young-Ho, Chen Yulong, Tan Xiaochao, Guo Lixia, Gibbons Don L, Ungewiss Christin, Peng David H, Liu Xin, Lin Steven H, Thilaganathan Nishan, Wistuba Ignacio I, Rodriguez-Canales Jaime, McLendon Georgia, Creighton Chad J, Kurie Jonathan M

Abstract excerpt

Epithelial tumor cells that have undergone epithelial-to-mesenchymal transition (EMT) are typically prone to metastasis and drug resistance and contribute to a poor clinical outcome. The transcription factor ZEB1 is a known driver of EMT, and mediators of ZEB1 represent potential therapeutic targets for metastasis suppression. Here, we have shown that phosphatidylinositol 3-kinase-targeted (PI3K-targeted) therapy...

Read the complete abstract on PubMed

Topics

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Share to Adenocarcinoma of Lung
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

Share to Neoplasm Metastasis

Share to Phosphatidylinositol 3-Kinases

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Receptor, ErbB-2

Share to Zinc Finger E-box-Binding Homeobox 1

Source

Open in PubMed Open full text

Identifiers

PMID: 24762440
DOI: 10.1172/JCI72171
PMCID: PMC4038569

Genes

ZEB1
AREG
BTC
EGFR
ERBB2
GATA3
GATA6
RHEB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism.PMID 24762440Read ↗

Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells.Semantic proximity Read ↗

ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expressionSemantic proximity Read ↗

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer.Semantic proximity Read ↗

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Pleiotropic Roles for ZEB1 in CancerSemantic proximity Read ↗

EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex.Semantic proximity Read ↗

ZEB/miR‐200 feedback loop: At the crossroads of signal transduction in cancerSemantic proximity Read ↗

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Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1α, POU/OCT, and NF-κBSemantic proximity Read ↗

MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agentsSemantic proximity Read ↗

ZEB1 in Pancreatic CancerSemantic proximity Read ↗

PTBP3-Mediated Regulation of ZEB1 mRNA Stability Promotes Epithelial–Mesenchymal Transition in Breast CancerSemantic proximity Read ↗

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