Article
ZEB1 drives epithelial-to-mesenchymal transition in lung cancer.
The Journal of clinical investigation - 1 Sept 2016
Larsen Jill E, Nathan Vaishnavi, Osborne Jihan K, Farrow Rebecca K, Deb Dhruba, Sullivan James P, Dospoy Patrick D, Augustyn Alexander, Hight Suzie K, Sato Mitsuo, Girard Luc, Behrens Carmen, Wistuba Ignacio I, Gazdar Adi F, Hayward Nicholas K, Minna John D
Abstract excerpt
Increased expression of zinc finger E-box binding homeobox 1 (ZEB1) is associated with tumor grade and metastasis in lung cancer, likely due to its role as a transcription factor in epithelial-to-mesenchymal transition (EMT). Here, we modeled malignant transformation in human bronchial epithelial cells (HBECs) and determined that EMT and ZEB1 expression are early, critical events in lung cancer pathogenesis....
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