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Article

Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells.

Cancer letters - 28 Oct 2010

Takeyama Yoshihiro, Sato Mitsuo, Horio Mihoko, Hase Tetsunari, Yoshida Kenya, Yokoyama Toshihiko, Nakashima Harunori, Hashimoto Naozumi, Sekido Yoshitaka, Gazdar Adi F, Minna John D, Kondo Masashi, Hasegawa Yoshinori

Abstract excerpt

We found that among four master epithelial-to-mesenchymal transition (EMT)-inducing genes (ZEB1, SIP1, Snail, and Slug) ZEB1expression was most significantly correlated with the mesenchymal phenotype (high Vimentin and low E-cadherin expression) in non-small cell lung cancer (NSCLC) cell lines and tumors. Furthermore, ZEB1 knockdown with RNA interference in three NSCLC cell lines with high ZEB1 expression...

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Identifiers

PMID: 20452118
DOI: 10.1016/j.canlet.2010.04.008
PMCID: PMC3110825

Genes

ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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