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Article

ZEB/miR‐200 feedback loop: At the crossroads of signal transduction in cancer

2 Jul 2012

Abstract excerpt

Embryonic differentiation programs of epithelial-mesenchymal and mesenchymal-epithelial transition (EMT and MET) represent a mechanistic basis for epithelial cell plasticity implicated in cancer. Transcription factors of the ZEB protein family (ZEB1 and ZEB2) and several microRNA species (predominantly miR-200 family members) form a double negative feedback loop, which controls EMT and MET programs in both...

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PMID: 22753312
DOI: 10.1002/ijc.27708

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