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Article

Influence of BDNF Val66Met polymorphism on excitatory-inhibitory balance and plasticity in human motor cortex.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology - 1 Nov 2021

Cash R F H, Udupa K, Gunraj C A, Mazzella F, Daskalakis Z J, Wong A H C, Kennedy J L, Chen R

Abstract excerpt

OBJECTIVE: While previous studies showed that the single nucleotide polymorphism (Val66Met) of brain-derived neurotrophic factor (BDNF) can impact neuroplasticity, the influence of BDNF genotype on cortical circuitry and relationship to neuroplasticity remain relatively unexplored in human. METHODS: Using individualised transcranial magnetic stimulation (TMS) parameters, we explored the influence of the BDNF...

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Identifiers

PMID: 34592560
DOI: 10.1016/j.clinph.2021.07.029

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