Article
Brain-derived neurotrophic factor (BDNF) gene polymorphisms shape cortical plasticity in humans.
Brain stimulation - 1 Oct 2010
Antal Andrea, Chaieb Leila, Moliadze Vera, Monte-Silva Katia, Poreisz Csaba, Thirugnanasambandam Nivethida, Nitsche Michael A, Shoukier Moneef, Ludwig Harald, Paulus Walter
Abstract excerpt
BACKGROUND: The brain-derived neurotrophic factor (BDNF) gene is involved in mechanisms of synaptic plasticity in the adult brain. It has been demonstrated that BDNF also plays a significant role in shaping externally induced human brain plasticity. Plasticity induced in the human motor cortex by intermittent theta-burst stimulation (iTBS) was impaired in individuals expressing the Val66Met polymorphism. METHODS:...
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