Article
Psoriasis patients are enriched for genetic variants that protect against HIV-1 disease.
PLoS genetics - 1 Feb 2012
Chen Haoyan, Hayashi Genki, Lai Olivia Y, Dilthey Alexander, Kuebler Peter J, Wong Tami V, Martin Maureen P, Fernandez Vina Marcelo A, McVean Gil, Wabl Matthias, Leslie Kieron S, Maurer Toby, Martin Jeffrey N, Deeks Steven G, Carrington Mary, Bowcock Anne M, Nixon Douglas F, Liao Wilson
Abstract excerpt
An important paradigm in evolutionary genetics is that of a delicate balance between genetic variants that favorably boost host control of infection but which may unfavorably increase susceptibility to autoimmune disease. Here, we investigated whether patients with psoriasis, a common immune-mediated disease of the skin, are enriched for genetic variants that limit the ability of HIV-1 virus to replicate after...
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