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Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes

23 Apr 2014

Abstract excerpt

Cancer genomes maintain a complex array of somatic alterations required for maintenance and progression of the disease, posing a challenge to identify driver genes among this genetic disorder. Toward this end, we mapped regions of recurrent amplification in a large collection (n=392) of primary human cancers and selected 620 genes whose expression is elevated in tumors. An RNAi loss-of-function screen targeting...

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PMID: 24755469
DOI: 10.1158/0008-5472.can-13-2683

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