Article
Genomic landscape and mutational impacts of recurrently mutated genes in cancers.
Molecular genetics & genomic medicine - 1 Nov 2018
Liu Baolin, Hu Fei-Fei, Zhang Qiong, Hu Hui, Ye Zheng, Tang Qin, Guo An-Yuan
Abstract excerpt
BACKGROUND: Cancer genes tend to be highly mutated under positive selection. Better understanding the recurrently mutated genes (RMGs) in cancer is critical for explicating the mechanisms of tumorigenesis and providing vital clues for therapy. Although some studies have investigated functional impacts of RMGs in specific cancer types, a comprehensive analysis of RMGs and their mutational impacts across cancers is...
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