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Article

Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis.

PLoS medicine - 27 May 2008

Chan Timothy A, Glockner Sabine, Yi Joo Mi, Chen Wei, Van Neste Leander, Cope Leslie, Herman James G, Velculescu Victor, Schuebel Kornel E, Ahuja Nita, Baylin Stephen B

Abstract excerpt

BACKGROUND: The identification and characterization of tumor suppressor genes has enhanced our understanding of the biology of cancer and enabled the development of new diagnostic and therapeutic modalities. Whereas in past decades, a handful of tumor suppressors have been slowly identified using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18507500
DOI: 10.1371/journal.pmed.0050114
PMCID: PMC2429944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18507500-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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