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Article

Shared and independent colorectal cancer risk alleles in TGFβ-related genes in African and European Americans.

Carcinogenesis - 1 Sept 2014

Kupfer Sonia S, Skol Andrew D, Hong Ellie, Ludvik Anton, Kittles Rick A, Keku Temitope O, Sandler Robert S, Ellis Nathan A

Abstract excerpt

Genome-wide association studies (GWAS) in colorectal cancer (CRC) identified five regions near transforming growth factor β-related genes BMP4, GREM1, CDH1, SMAD7 and RPHN2. The true risk alleles remain to be identified in these regions, and their role in CRC risk in non-European populations has been understudied. Our previous work noted significant genetic heterogeneity between African Americans (AAs) and...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24753543
DOI: 10.1093/carcin/bgu088
PMCID: PMC4146413

Genes

GREM1
CDH1
BMP4
RHPN2
SMAD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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