Article
Characterization of gene-environment interactions for colorectal cancer susceptibility loci.
Cancer research - 15 Apr 2012
Hutter Carolyn M, Chang-Claude Jenny, Slattery Martha L, Pflugeisen Bethann M, Lin Yi, Duggan David, Nan Hongmei, Lemire Mathieu, Rangrej Jagadish, Figueiredo Jane C, Jiao Shuo, Harrison Tabitha A, Liu Yan, Chen Lin S, Stelling Deanna L, Warnick Greg S, Hoffmeister Michael, Küry Sébastien, Fuchs Charles S, Giovannucci Edward, Hazra Aditi, Kraft Peter, Hunter David J, Gallinger Steven, Zanke Brent W, Brenner Hermann, Frank Bernd, Ma Jing, Ulrich Cornelia M, White Emily, Newcomb Polly A, Kooperberg Charles, LaCroix Andrea Z, Prentice Ross L, Jackson Rebecca D, Schoen Robert E, Chanock Stephen J, Berndt Sonja I, Hayes Richard B, Caan Bette J, Potter John D, Hsu Li, Bézieau Stéphane, Chan Andrew T, Hudson Thomas J, Peters Ulrike
Abstract excerpt
Genome-wide association studies (GWAS) have identified more than a dozen loci associated with colorectal cancer (CRC) risk. Here, we examined potential effect-modification between single-nucleotide polymorphisms (SNP) at 10 of these loci and probable or established environmental risk factors for CRC in 7,016 CRC cases and 9,723 controls from nine cohort and case-control studies. We used meta-analysis of an...
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