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Article

Induction of C/EBPα activity alters gene expression and differentiation of human CD34+ cells

27 Feb 2003

Abstract excerpt

The CCAAT/enhancer binding protein alpha (C/EBPalpha) belongs to a family of transcription factors that are involved in the differentiation process of numerous tissues, including the liver and hematopoietic cells. C/EBPalpha(-/-) mice show a block in hematopoietic differentiation, with an accumulation of myeloblasts and an absence of mature granulocytes, whereas expression of C/EBPalpha in leukemia cell lines...

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PMID: 12406909
DOI: 10.1182/blood-2002-05-1546

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