Article
Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer.
Nature biotechnology - 1 May 2014
Lohr Jens G, Adalsteinsson Viktor A, Cibulskis Kristian, Choudhury Atish D, Rosenberg Mara, Cruz-Gordillo Peter, Francis Joshua M, Zhang Cheng-Zhong, Shalek Alex K, Satija Rahul, Trombetta John J, Lu Diana, Tallapragada Naren, Tahirova Narmin, Kim Sora, Blumenstiel Brendan, Sougnez Carrie, Lowe Alarice, Wong Bang, Auclair Daniel, Van Allen Eliezer M, Nakabayashi Mari, Lis Rosina T, Lee Gwo-Shu M, Li Tiantian, Chabot Matthew S, Ly Amy, Taplin Mary-Ellen, Clancy Thomas E, Loda Massimo, Regev Aviv, Meyerson Matthew, Hahn William C, Kantoff Philip W, Golub Todd R, Getz Gad, Boehm Jesse S, Love J Christopher
Abstract excerpt
Comprehensive analyses of cancer genomes promise to inform prognoses and precise cancer treatments. A major barrier, however, is inaccessibility of metastatic tissue. A potential solution is to characterize circulating tumor cells (CTCs), but this requires overcoming the challenges of isolating rare cells and sequencing low-input material. Here we report an integrated process to isolate, qualify and sequence...
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