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Article

Circulating tumor cells capture disease evolution in advanced prostate cancer.

Journal of translational medicine - 23 Feb 2017

Lack Justin, Gillard Marc, Cam Maggie, Paner Gladell P, VanderWeele David J

Abstract excerpt

BACKGROUND: Genetic analysis of advanced cancer is limited by availability of representative tissue. Biopsies of prostate cancer metastasized to bone are invasive with low quantity of tumor tissue. The prostate cancer genome is dynamic, however, with temporal heterogeneity requiring repeated evaluation as the disease evolves. Circulating tumor cells (CTCs) offer an alternative, "liquid biopsy", though single CTC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28228136
DOI: 10.1186/s12967-017-1138-3
PMCID: PMC5322599

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