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Article

A comparison of isolated circulating tumor cells and tissue biopsies using whole-genome sequencing in prostate cancer.

Oncotarget - 29 Dec 2015

Jiang Runze, Lu Yi-Tsung, Ho Hao, Li Bo, Chen Jie-Fu, Lin Millicent, Li Fuqiang, Wu Kui, Wu Hanjie, Lichterman Jake, Wan Haolei, Lu Chia-Lun, OuYang William, Ni Ming, Wang Linlin, Li Guibo, Lee Tom, Zhang Xiuqing, Yang Jonathan, Rettig Matthew, Chung Leland W K, Yang Huanming, Li Ker-Chau, Hou Yong, Tseng Hsian-Rong, Hou Shuang, Xu Xun, Wang Jun, Posadas Edwin M

Abstract excerpt

Previous studies have demonstrated focal but limited molecular similarities between circulating tumor cells (CTCs) and biopsies using isolated genetic assays. We hypothesized that molecular similarity between CTCs and tissue exists at the single cell level when characterized by whole genome sequencing (WGS). By combining the NanoVelcro CTC Chip with laser capture microdissection (LCM), we developed a platform for...

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Identifiers

PMID: 26575023
DOI: 10.18632/oncotarget.6330
PMCID: PMC4792591

Genes

BRCA2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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