Article
MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1 through KAT2A in mice.
British journal of haematology - 1 Jul 2014
Tao Yunlong, Wu Qian, Guo Xin, Zhang Zhuzhen, Shen Yuanyuan, Wang Fudi
Abstract excerpt
Ferritin plays important roles in iron metabolism and controls iron absorption in the intestine. The ferritin subunits ferritin heavy chain (Fth1) and ferritin light chain (Ftl1) are tightly regulated at both the transcriptional and post-transcriptional levels. However, mechanisms of maintaining stable, basal expression of Fth1 are poorly understood. Here, we show that global deletion of Mbd5 in mice induces an...
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