Article

Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux

2025-02-27

Abstract excerpt

Cellular iron levels must be tightly regulated to ensure sufficient iron for essential enzymatic functions whilst avoiding the harmful generation of toxic species. Here, to better understand how iron levels are controlled, we carry out genome-wide mutagenesis screens in human cells. Alongside mapping known components of iron-sensing, we determine the relative contributions of iron uptake, iron recycling, ferritin...

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Identifiers and source

Literature Corpus work: 82cebc02-5629-534c-aa07-97e55d4dabf3
DOI: 10.1101/2025.02.26.640314

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