Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux.

doi:10.1126/sciadv.adw9095

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Article

Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux.

Science advances - 19 Sept 2025

Martinelli Anthony W, Wu Chun-Pei, Vornbäumen Tristan, Coates Hudson W, Jordon Louise H, Wit Niek, Sia Jia J, Speak Anneliese O, Nathan James A

Abstract excerpt

Cellular iron levels must be tightly regulated to ensure sufficient iron for essential enzymatic functions while avoiding the harmful generation of toxic species. Here, to better understand how iron levels are controlled, we carry out genome-wide mutagenesis screens in human cells. Alongside mapping known components of iron sensing, we determine the relative contributions of iron uptake, iron recycling, ferritin...

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Identifiers

PMID: 40961184
DOI: 10.1126/sciadv.adw9095
PMCID: PMC12442849

Genes

SETD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.