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Article

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.

Cell metabolism - 1 Dec 2005

Wang Rui-Hong, Li Cuiling, Xu Xiaoling, Zheng Yin, Xiao Cuiying, Zerfas Patricia, Cooperman Sharon, Eckhaus Michael, Rouault Tracey, Mishra Lopa, Deng Chu-Xia

Abstract excerpt

Hereditary hemochromatosis, characterized by iron overload in multiple organs, is one of the most common genetic disorders among Caucasians. Hepcidin, which is synthesized in the liver, plays important roles in iron overload syndromes. Here, we show that a Cre-loxP-mediated liver-specific disruption of SMAD4 results in markedly decreased hepcidin expression and accumulation of iron in many organs, which is most...

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Source

Identifiers

PMID: 16330325
DOI: 10.1016/j.cmet.2005.10.010

Genes

SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.PMID 16330325Read ↗

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