Article
Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice.
Advances in biological regulation - 1 May 2020
Hale Andrew T, Brown Rachel E, Luka Zigmund, Hudson Benjamin H, Matta Pranathi, Williams Christopher S, York John D
Abstract excerpt
Sulfur assimilation is an essential metabolic pathway that regulates sulfation, amino acid metabolism, nucleotide hydrolysis, and organismal homeostasis. We recently reported that mice lacking bisphosphate 3'-nucleotidase (BPNT1), a key regulator of sulfur assimilation, develop iron-deficiency anemia (IDA) and anasarca. Here we demonstrate two approaches that successfully reduce metabolic toxicity caused by loss...
Topics
- Anemia, Iron-Deficiency
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Diet
- Disease Models, Animal
- Female
- Gene Expression Regulation
- Hemochromatosis
- Hemochromatosis Protein
- Homeostasis