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Article

Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice.

Advances in biological regulation - 1 May 2020

Hale Andrew T, Brown Rachel E, Luka Zigmund, Hudson Benjamin H, Matta Pranathi, Williams Christopher S, York John D

Abstract excerpt

Sulfur assimilation is an essential metabolic pathway that regulates sulfation, amino acid metabolism, nucleotide hydrolysis, and organismal homeostasis. We recently reported that mice lacking bisphosphate 3'-nucleotidase (BPNT1), a key regulator of sulfur assimilation, develop iron-deficiency anemia (IDA) and anasarca. Here we demonstrate two approaches that successfully reduce metabolic toxicity caused by loss...

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Identifiers

PMID: 32019729
DOI: 10.1016/j.jbior.2020.100694
PMCID: PMC7230019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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