Article
Iron regulatory proteins control a mucosal block to intestinal iron absorption.
Cell reports - 28 Mar 2013
Galy Bruno, Ferring-Appel Dunja, Becker Christiane, Gretz Norbert, Gröne Hermann-Josef, Schümann Klaus, Hentze Matthias W
Abstract excerpt
Mammalian iron metabolism is regulated systemically by the hormone hepcidin and cellularly by iron regulatory proteins (IRPs) that orchestrate a posttranscriptional regulatory network. Through ligand-inducible genetic ablation of both IRPs in the gut epithelium of adult mice, we demonstrate that IRP deficiency impairs iron absorption and promotes mucosal iron retention via a ferritin-mediated "mucosal block." We...
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