Article
Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver.
Scientific reports - 6 Apr 2016
Foot Natalie J, Gembus Kelly M, Mackenzie Kimberly, Kumar Sharad
Abstract excerpt
The regulation of divalent metal ion transporter DMT1, the primary non-heme iron importer in mammals, is critical for maintaining iron homeostasis. Previously we identified ubiquitin-dependent regulation of DMT1 involving the Nedd4 family of ubiquitin ligases and the Ndfip1 and Ndfip2 adaptors. We also established the in vivo function of Ndfip1 in the regulation of DMT1 in the duodenum of mice. Here we have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.