Article
Development of a robust and sensitive pyrosequencing assay for the detection of IDH1/2 mutations in gliomas.
Brain tumor pathology - 1 Jan 2015
Arita Hideyuki, Narita Yoshitaka, Matsushita Yuko, Fukushima Shintaro, Yoshida Akihiko, Takami Hirokazu, Miyakita Yasuji, Ohno Makoto, Shibui Soichiro, Ichimura Koichi
Abstract excerpt
Assessment of the mutational status of the isocitrate dehydrogenase 1/2 (IDH1/2) gene has become an integral part of the standard diagnostic procedure and, therefore, needs to be accurate. This may, however, be compromised by various factors including the method of analysis and a low tumor cell content. We have developed a rapid, sensitive and robust assay to detect all types of mutation in either IDH1 or IDH2...
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