Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IDH1 mutations in oligodendroglial tumors: comparative analysis of direct sequencing, pyrosequencing, immunohistochemistry, nested PCR and PNA-mediated clamping PCR.

Brain pathology (Zurich, Switzerland) - 1 May 2013

Lee Dakeun, Suh Yeon-Lim, Kang So Young, Park Tae-In, Jeong Ji Yun, Kim Se-Hoon

Abstract excerpt

Mutations in isocitrate dehydrogenase 1 (IDH1) are found in a high proportion of glial tumors and have a significant prognostic impact. Although direct sequencing has been considered to be the gold-standard method to detect this mutation, the sensitivity of this technique has been questioned especially because specimens from glial tumors may contain large numbers of non-tumor cells. We screened 141 cases of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to Isocitrate Dehydrogenase

Share to Kaplan-Meier Estimate

Share to Oligodendroglia

Share to Peptide Nucleic Acids

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 23072665
DOI: 10.1111/bpa.12000
PMCID: PMC8029453

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IDH1 mutations in oligodendroglial tumors: comparative analysis of direct sequencing, pyrosequencing, immunohistochemistry, nested PCR and PNA-mediated clamping PCR.PMID 23072665Read ↗

Estimation of the occurrence rates of IDH1 and IDH2 mutations in gliomas and the reconsideration of IDH-wildtype anaplastic astrocytomas: an institutional experience.Semantic proximity Read ↗

Rapid and sensitive assessment of the IDH1 and IDH2 mutation status in cerebral gliomas based on DNA pyrosequencing.Semantic proximity Read ↗

Pyrosequencing of IDH1 and IDH2 mutations in brain tumors and non-neoplastic conditions.Semantic proximity Read ↗

IDH1 mutation analysis in low cellularity specimen: a limitation of diagnostic accuracy and a proposal for the diagnostic procedure.Semantic proximity Read ↗

Qualitative and Quantitative Analysis of IDH1 Mutation in Progressive Gliomas by Allele-Specific qPCR and Western Blot AnalysisSemantic proximity Read ↗

A pyrosequencing-based assay for the rapid detection of IDH1 mutations in clinical samples.Semantic proximity Read ↗

Mutation-specific IDH1 antibody differentiates oligodendrogliomas and oligoastrocytomas from other brain tumors with oligodendroglioma-like morphology.Semantic proximity Read ↗

Comparison of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism, Immunohistochemistry, and DNA Sequencing for the Detection of IDH1 Mutations in Gliomas.Semantic proximity Read ↗

A novel high-sensitivity assay to detect a small fraction of mutant IDH1 using droplet digital PCR.Semantic proximity Read ↗

[Feature analysis of IDH1 mutation in oligodendroglial tumors].Semantic proximity Read ↗

A rare case of oligodendroglioma with gangliocytic differentiation in a 31-year-old male: importance of genetic testing for IDH1/2.Semantic proximity Read ↗

Development of a robust and sensitive pyrosequencing assay for the detection of IDH1/2 mutations in gliomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.