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Article

Rapid and sensitive assessment of the IDH1 and IDH2 mutation status in cerebral gliomas based on DNA pyrosequencing.

Acta neuropathologica - 1 Apr 2010

Felsberg Jörg, Wolter Marietta, Seul Heike, Friedensdorf Britta, Göppert Matthias, Sabel Michael C, Reifenberger Guido

Abstract excerpt

Diffusely infiltrating cerebral gliomas frequently carry point mutations in codon 132 of the isocitrate dehydrogenase 1 (IDH1) gene or in codon 172 of the IDH2 gene, which are both clinically important as diagnostic and prognostic markers. Here, we report on a method that allows for the rapid detection of IDH1 and IDH2 mutations based on pyrosequencing. The method is applicable to routinely processed tissue...

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Source

Identifiers

PMID: 20131059
DOI: 10.1007/s00401-010-0647-4

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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