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Article

Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome.

Neurobiology of disease - 1 Jan 2015

Rubinstein Moran, Westenbroek Ruth E, Yu Frank H, Jones Christina J, Scheuer Todd, Catterall William A

Abstract excerpt

Dominant loss-of-function mutations in voltage-gated sodium channel NaV1.1 cause Dravet Syndrome, an intractable childhood-onset epilepsy. NaV1.1(+/-) Dravet Syndrome mice in C57BL/6 genetic background exhibit severe seizures, cognitive and social impairments, and premature death. Here we show that Dravet Syndrome mice in pure 129/SvJ genetic background have many fewer seizures and much less premature death than...

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Source

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Identifiers

PMID: 25281316
DOI: 10.1016/j.nbd.2014.09.017
PMCID: PMC4254180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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