Article

GIRK Channel Loss of Function Increases Dendritic Excitability in a Mouse Model of GNB1 Encephalopathy

2026-08-13

Abstract excerpt

GNB1 encephalopathy (GNB1-E) is a rare neurodevelopmental disorder associated with motor dysfunction, epilepsy and learning disability caused by mutations in the gene encoding the G protein subunit Gβ 1 . Previous work has shown that altered Gβ 1 can disrupt activation of G-protein-coupled inwardly rectifying potassium (GIRK) channels, dysregulate neuronal excitability and cause seizures. However, the relevant u...

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Literature Corpus work: 80af56be-a456-5a14-b028-7f444256403d
DOI: 10.64898/2026.08.08.743706

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