Article
GCN5 is involved in regulation of immunoglobulin heavy chain gene expression in immature B cells.
Gene - 1 Jul 2014
Kikuchi Hidehiko, Nakayama Masami, Kuribayashi Futoshi, Imajoh-Ohmi Shinobu, Nishitoh Hideki, Takami Yasunari, Nakayama Tatsuo
Abstract excerpt
GCN5 is involved in the acetylation of core histones, which is an important epigenetic event for transcriptional regulation through alterations in the chromatin structure in eukaryotes. To investigate physiological roles of GCN5, we have systematically analyzed phenotypes of homozygous GCN5-deficient DT40 mutants. Here, we report participation of GCN5 in regulation of IgM heavy chain (H-chain) gene expression....
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