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Article

GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk.

Biochemical and biophysical research communications - 25 Feb 2011

Kikuchi Hidehiko, Kuribayashi Futoshi, Takami Yasunari, Imajoh-Ohmi Shinobu, Nakayama Tatsuo

Abstract excerpt

Histone acetyltransferase(s) (HATs) are involved in the acetylation of core histones, which is an important event for transcription regulation through alterations in the chromatin structure in eukaryotes. General control non-depressible 5 (GCN5) was first identified as a global coactivator and transcription-related HAT. Here we report that GCN5 regulates the activation of phosphatidylinositol 3-kinase...

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PMID: 21281601
DOI: 10.1016/j.bbrc.2011.01.088

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