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Article

Transcriptional Activation of MYC-Induced Genes by GCN5 Promotes B-cell Lymphomagenesis.

Cancer research - 15 Dec 2020

Farria Aimee T, Plummer Joshua B, Salinger Andrew P, Shen Jianjun, Lin Kevin, Lu Yue, McBride Kevin M, Koutelou Evangelia, Dent Sharon Y R

Abstract excerpt

Overexpression of the MYC oncoprotein is an initiating step in the formation of several cancers. MYC frequently recruits chromatin-modifying complexes to DNA to amplify the expression of cancer-promoting genes, including those regulating cell cycle, proliferation, and metabolism, yet the roles of specific modifiers in different cancer types are not well defined. Here, we show that GCN5 is an essential coactivator...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, B-Cell

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Source

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Identifiers

PMID: 33168647
DOI: 10.1158/0008-5472.CAN-20-2379
PMCID: PMC7744430

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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