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Article

Multifactorial ERβ and NOTCH1 control of squamous differentiation and cancer

16 Apr 2014

Abstract excerpt

Downmodulation or loss-of-function mutations of the gene encoding NOTCH1 are associated with dysfunctional squamous cell differentiation and development of squamous cell carcinoma (SCC) in skin and internal organs. While NOTCH1 receptor activation has been well characterized, little is known about how NOTCH1 gene transcription is regulated. Using bioinformatics and functional screening approaches, we identified...

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PMID: 24743148
DOI: 10.1172/jci72718

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