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Mutant p63 Affects Epidermal Cell Identity through Rewiring the Enhancer Landscape

1 Dec 2018

Abstract excerpt

Transcription factor p63 is a key regulator of epidermal keratinocyte proliferation and differentiation. Mutations in the p63 DNA-binding domain are associated with ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome. However, the underlying molecular mechanism of these mutations remains unclear. Here, we characterized the transcriptome and epigenome of p63 mutant keratinocytes derived from...

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PMID: 30566872
DOI: 10.1016/j.celrep.2018.11.039

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