Article
Whole-Exome and Transcriptome Analysis of UV-Exposed Epidermis and Carcinoma In Situ Reveals Early Drivers of Carcinogenesis.
The Journal of investigative dermatology - 1 Feb 2021
Zheng Qi, Capell Brian C, Parekh Vishwas, O'Day Conor, Atillasoy Cem, Bashir Hasan M, Yeh Christopher, Shim Eun-Hee, Prouty Stephen M, Dentchev Tzvete, Lee Vivian, Wushanley Lily, Kweon Yerin, Suzuki-Horiuchi Yoko, Pear Warren, Grice Elizabeth A, Seykora John T
Abstract excerpt
Squamous cell carcinoma in situ (SCCIS) is a prevalent precancerous lesion that can progress to cutaneous squamous cell carcinoma. Although SCCIS is common, its pathogenesis remains poorly understood. To better understand SCCIS development, we performed laser captured microdissection of human SCCIS and the adjacent epidermis to isolate genomic DNA and RNA for next-generation sequencing. Whole-exome sequencing...
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