Article

Estrogen Receptors/E2F1/CDKN3 Axis Protects from UV-induced Skin Cancers in Females

2025-02-16

Abstract excerpt

Men have a significantly higher risk of developing cutaneous squamous cell carcinoma (SCC) compared to women, but models and comprehensive analysis of signaling pathways highlighting this sexual dimorphism are missing. In this study, we display a UV-induced SCC model in hairless mice recapitulating this sex difference, with enhanced SCC development in males. While UV-induced DNA damage is similar between sexes, we...

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Literature Corpus work: dd2d344e-718e-500a-bc5e-84c6bf9ffa6f
DOI: 10.1101/2025.02.12.637819

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