Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population.

doi:10.1111/adb.12141

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population.

Addiction biology - 1 May 2015

Way Michael, McQuillin Andrew, Saini Jit, Ruparelia Kush, Lydall Gregory J, Guerrini Irene, Ball David, Smith Iain, Quadri Giorgia, Thomson Allan D, Kasiakogia-Worlley Katherine, Cherian Raquin, Gunwardena Priyanthi, Rao Harish, Kottalgi Girija, Patel Shamir, Hillman Audrey, Douglas Ewen, Qureshi Sherhzad Y, Reynolds Gerry, Jauhar Sameer, O'Kane Aideen, Dedman Alex, Sharp Sally, Kandaswamy Radhika, Dar Karim, Curtis David, Morgan Marsha Y, Gurling Hugh M D

Abstract excerpt

Certain single nucleotide polymorphisms (SNPs) in genes encoding alcohol dehydrogenase (ADH) enzymes confer a significant protective effect against alcohol dependence syndrome (ADS) in East Asian populations. Recently, attention has focused on the role of these SNPs in determining ADS risk in European populations. To further elucidate these associations, SNPs of interest in ADH1B, ADH1C and the ADH1B/1C...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alcoholism

Share to Case-Control Studies

Share to Genetic Predisposition to Disease

Share to Genetic Variation

Share to Ireland

Share to Polymorphism, Single Nucleotide

Share to United Kingdom

Source

Open in PubMed

Identifiers

PMID: 24735490
DOI: 10.1111/adb.12141

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population.PMID 24735490Read ↗

Genetic variants in ALDH1B1 and alcohol dependence risk in a British and Irish population: A bioinformatic and genetic study.Semantic proximity Read ↗

Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases.Semantic proximity Read ↗

Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.Semantic proximity Read ↗

ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry.Semantic proximity Read ↗

Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C.Semantic proximity Read ↗

Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases.Semantic proximity Read ↗

Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.Semantic proximity Read ↗

Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical ReviewSemantic proximity Read ↗

Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma.Semantic proximity Read ↗

Impacts of ADH1B rs1229984 and ALDH2 rs671 polymorphisms on risks of alcohol-related disorder and cancer.Semantic proximity Read ↗

Rare ADH variant constellations are specific for alcohol dependence.Semantic proximity Read ↗

Alcohol-metabolizing genes and alcohol phenotypes in an Israeli household sample.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.