Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C.

PloS one - 1 Jan 2013

Biernacka Joanna M, Geske Jennifer R, Schneekloth Terry D, Frye Mark A, Cunningham Julie M, Choi Doo-Sup, Tapp Courtney L, Lewis Bradley R, Drews Maureen S, L Pietrzak Tracy, Colby Colin L, Hall-Flavin Daniel K, Loukianova Larissa L, Heit John A, Mrazek David A, Karpyak Victor M

Abstract excerpt

Genome-wide association studies (GWAS) have revealed many single nucleotide polymorphisms (SNPs) associated with complex traits. Although these studies frequently fail to identify statistically significant associations, the top association signals from GWAS may be enriched for true associations. We therefore investigated the association of alcohol dependence with 43 SNPs selected from association signals in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Dehydrogenase
Share to Alcoholism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 23516558
DOI: 10.1371/journal.pone.0058798
PMCID: PMC3596339

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C.PMID 23516558Read ↗

Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.Semantic proximity Read ↗

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.Semantic proximity Read ↗

Genome-wide association study of alcohol dependence.Semantic proximity Read ↗

Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.Semantic proximity Read ↗

Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population.Semantic proximity Read ↗

Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases.Semantic proximity Read ↗

Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.Semantic proximity Read ↗

Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical ReviewSemantic proximity Read ↗

Overview of the Genetics of Alcohol Use Disorder.Semantic proximity Read ↗

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117).Semantic proximity Read ↗

ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry.Semantic proximity Read ↗

Interaction of alcohol consumption and genetic variants in alcohol metabolism on all-cause and disease-specific mortality: a cohort studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.