Article
Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.
Nature genetics - 1 May 2014
Styrkarsdottir Unnur, Thorleifsson Gudmar, Helgadottir Hafdis T, Bomer Nils, Metrustry Sarah, Bierma-Zeinstra S, Strijbosch Annelieke M, Evangelou Evangelos, Hart Deborah, Beekman Marian, Jonasdottir Aslaug, Sigurdsson Asgeir, Eiriksson Finnur F, Thorsteinsdottir Margret, Frigge Michael L, Kong Augustine, Gudjonsson Sigurjon A, Magnusson Olafur T, Masson Gisli, Hofman Albert, Arden Nigel K, Ingvarsson Thorvaldur, Lohmander Stefan, Kloppenburg Margreet, Rivadeneira Fernando, Nelissen Rob G H H, Spector Tim, Uitterlinden Andre, Slagboom P Eline, Thorsteinsdottir Unnur, Jonsdottir Ingileif, Valdes Ana M, Meulenbelt Ingrid, van Meurs Joyce, Jonsson Helgi, Stefansson Kari
Abstract excerpt
Osteoarthritis is the most common form of arthritis and is a major cause of pain and disability in the elderly. To search for sequence variants that confer risk of osteoarthritis of the hand, we carried out a genome-wide association study (GWAS) in subjects with severe hand osteoarthritis, using variants identified through the whole-genome sequencing of 2,230 Icelanders. We found two significantly associated loci...
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