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Article

A functional variant of ALDH1A2 is associated with hand osteoarthritis in the Chinese population.

International journal of immunogenetics - 1 Jun 2024

Dai Jian, Jiang Haitao, Yang Zhaoqi, Chen Chuan, Tang Xiaoming

Abstract excerpt

Genome-wide association study identified common variants within the ALDH1A2 gene as the susceptible loci of hand osteoarthritis (HOA) in UK and Iceland populations. Located in chromosome 15, ALDH1A2 encodes aldehyde dehydrogenase family 1 member A2, which is an enzyme that catalyses the synthesis of retinoic acid from retinaldehyde. Our purposes were to replicate the association of functional variant in ALDH1A2...

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Identifiers

PMID: 38441233
DOI: 10.1111/iji.12662

Genes

ALDH1A2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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