Article
Genomewide scan for hand osteoarthritis: a novel mutation in matrilin-3.
American journal of human genetics - 1 Jun 2003
Stefánsson Stefán Einar, Jónsson Helgi, Ingvarsson Thorvaldur, Manolescu Ileana, Jónsson Hjörtur H, Olafsdóttir Gudbjörg, Pálsdóttir Ebba, Stefánsdóttir Gerdur, Sveinbjörnsdóttir Gudfinna, Frigge Michael L, Kong Augustine, Gulcher Jeffrey R, Stefánsson Kári
Abstract excerpt
Osteoarthritis (OA) is the most common human joint disease, characterized by loss and/or remodeling of joint synovium, cartilage, and bone. Here, we describe a genomewide linkage analysis of patients with idiopathic hand OA who were carefully phenotyped for involvement of either or both the distal interphalangeal (DIP) joints and the first carpometacarpal (CMC1) joints. The best linkage peaks were on chromosomes...
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