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Article

Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Oct 2018

Shepherd Colin, Zhu Dongxing, Skelton Andrew J, Combe Jennifer, Threadgold Harrison, Zhu Linyi, Vincent Tonia L, Stuart Paul, Reynard Louise N, Loughlin John

Abstract excerpt

OBJECTIVE: To identify the functional single-nucleotide polymorphisms (SNPs) and mechanisms conferring increased risk of hand osteoarthritis (OA) at the ALDH1A2 locus, which is a retinoic acid regulatory gene. METHODS: Tissue samples from 247 patients with knee, hip, or hand OA who had undergone joint surgery were included. RNA-sequencing analysis was used to investigate differential expression of ALDH1A2 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29732726
DOI: 10.1002/art.40545
PMCID: PMC6175168

Genes

SOX9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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